Skin Care
Biomodulators vs Dermal Fillers: What’s the Difference?
13 Nov 2025
5 min read
Biomodulators and dermal fillers are both injectable treatments with anti-ageing, rejuvenating effects. However, they differ in how they work and the results they achieve. Read on to learn which best matches your skin goals.
What are Biomodulators?
Biomodulators, also referred to as biostimulators, are substances that regulate or change a biological function, such as triggering the body’s natural healing and repair process to increase collagen and elastin production, with long-term skin-boosting effects.
By boosting collagen and elastin levels, these active agents build structural support within the skin, firming and restoring volume, smoothing even deep wrinkles and signs of sagging, making this treatment type ideal for mature skin and those seeking proactive anti-ageing methods.
What are Dermal Fillers?
Dermal fillers are gel-like substances used to add and restore volume, pushing the skin up to smooth lines and enhance facial contours with instant results.
Usually made from hyaluronic acid, dermal fillers can also be used to plump lips, define the jawline and shape the nose, with results tailored to the individual's anatomy and treatment goals. The type of filler used depends on the area to be treated, with its firmness and flexibility matched to the treatment area. The lip area requires a softer, more fluid material, while filler injected to enhance bone structure and provide projection must be stronger and less flexible.
Results are temporary, typically lasting from 6 to 18 months, depending on the type of filler used, lifestyle factors and the individual's natural metabolism.
Differences Between Biomodulators and Dermal Fillers
The key difference between biomodulators and dermal fillers lies in the way they work, how quickly they take effect and how long they last, while fillers physically fill the skin, for immediate effects that wear off over time, biomodulators activate the body’s natural regenerative processes to create gradual, long-lasting and natural-looking results supported by natural collagen stores.
Biomodulators are also known to be more versatile, providing wider tissue improvements beyond adding volume, improving overall skin quality, hydration and radiance for bouncy, even-toned skin that glows from within.
Which Treatment is Right for You?
It's clear that there are benefits to both biomodulators and dermal fillers—CurrentBody Skin: The Clinic offers a number of these complexion-enhancing injectables, whether you’re seeking instant results or skin-boosting treatments that supercharge skin health from the inside out.
Sculptra: This FDA-approved skin-boosting injectable contains poly-L-lactic acid (PLLA), a biocompatible substance derived from lactic acid, to trigger the body’s natural repair process and encourage collagen production, building gradual volume over time by improving the thickness, elasticity and overall quality of skin.
JULÄINE™: Like Sculptra, Juläine uses PLLA as its core material to increase collagen and elastin levels within the skin, helping to improve texture and firmness to reverse signs of ageing, but with an advanced formulation reducing the need for post-treatment massage, for a better patient experience.
RADIESSE: Suitable for even the deepest wrinkles and signs of ageing, Radiesse is a dual-action injectable, both a biostimulator and dermal filler. While the gel carrier provides instant volume, Calcium Hydroxylapatite (CaHa) microspheres trigger collagen and elastin production, acting as a scaffolding with long-lasting effects.
Dermal Fillers: Dermal fillers allow for versatile treatments that go beyond anti-ageing with immediate effects. CurrentBody Skin: The Clinic uses Teosyal dermal fillers, a premium hyaluronic acid-based product to deliver natural-looking results, whatever your beauty goal.
Our team of experienced and highly trained practitioners are on hand to recommend which treatment is best for you based on your skin type and desired outcome. Book a consultation at CurrentBody Skin: The Clinic today to unlock naturally smoother, firmer skin from within and turn back the clock on ageing.
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